10 Best US Cities to Open a Dispensary

Here is an overview of the 10 best U.S. cities for opening a dispensary. We consider factors such as population density, local laws, and market potential. By selecting a strategic location, you can maximize your chances of running a thriving cannabis dispensary.

1. Jersey City, New Jersey 

The East Coast boasts a rapidly growing cannabis market in nearly every legal state, and New Jersey is no exception. The recreational program is overseen by the New Jersey Cannabis Regulatory Commission. Jersey City is an appealing choice to open a dispensary because it is the second-largest city in the state and is notable for being one of the few areas in NJ that does not have a cap on the number of retail establishments allowed within the municipality. 

Opening a dispensary here is not a fast or easy process, but with a little planning and strategic execution, there is opportunity to be seized. Key considerations for opening a dispensary in Jersey City include: 

• Business operations. You must have a business entity, a fully formed business plan, and have secured a physical location before you apply for a retail license, including a competitive analysis. 
• Secure funding. Opening a dispensary in New Jersey requires a lot of capital upfront, as well as taxes and fees, and license applications require you to disclose where the money is coming from. 
• Obtain required licenses. Apply for and secure a retail license from the New Jersey Cannabis Regulatory Commission (CRC). 
• Ensure Compliance: Adhere to New Jersey and Jersey City’s regulations, including operational, safety, reporting, insurance, and employee training standards.

2. Seattle, Washington

As an early adopter of recreational cannabis, Seattle offers a mature market and supportive community for cannabis businesses. The city’s progressive attitude and tourism industry create a favorable environment for opening a dispensary, with ample opportunities for success in an innovative and dynamic market.

Budding cannabis entrepreneurs looking to open a dispensary in Washington must consider the local laws and look into the state’s licensing process and regulations. For a comprehensive insight into starting your cannabis business in the state, read our guide to opening a dispensary in Washington.

In a competitive market like Seattle’s cannabis industry, understanding the landscape is vital for success. Here are key strategies to consider when evaluating your prospects and establishing a strong foothold in the industry:

• Consider the Competitive Landscape: Evaluate the dynamics of the cannabis industry in well-established markets like Seattle to understand your prospects.
• Network and Collaborate: Engage with fellow industry players to gain valuable insights, identify hidden opportunities, and build strategic partnerships.
• Leverage Strategic Alliances: Building strong partnerships can enhance your business prospects; for instance, collaborating with a local distributor can help you access a broader customer base while sharing marketing resources to increase brand visibility.

3. San Francisco, California

The Bay Area, particularly San Francisco, is another attractive option with its established cannabis market,  favorable demographics, and long history of cannabis culture acceptance. San Francisco offers a strong customer base consisting of high-income residents and millions of tourists each year.

The city’s progressive values and innovative spirit also provide opportunities for dispensaries to differentiate themselves by focusing on niche markets and unique retail experiences. Although California’s regulatory environment can be complex, the state has made efforts to streamline the process for cannabis businesses. Entrepreneurs who can successfully navigate the licensing requirements and operational guidelines have the potential to thrive in this competitive market.

Here are key considerations for opening a dispensary in San Francisco:

• Obtain Required Licenses: Secure a retail dispensary license from the Bureau of Cannabis Control and comply with local regulations, including zoning restrictions and obtaining a permit from the Office of Cannabis.
• Plan for Taxes and Fees: Factor in various taxes and fees in your business planning to ensure financial viability.
• Navigate Local Laws and Demographics: Understand local laws and leverage the city’s demographics to optimize your business strategy, along with obtaining appropriate cannabis insurance specific to San Francisco.
  

To get a full overview of the process of opening a dispensary, including requirements and procedures, read our complete guide to opening a dispensary in California. 

LA gets an honorable mention here as well. The City of Angels has many dispensaries, including some that also serve as consumption lounges like The Woods WeHo. Given the density of retail locations in LA, it’s important to know what differentiates your dispensary from the dozens of others here before you embark on the long journey of opening here.

4. Las Vegas, Nevada

Since Nevada legalized recreational marijuana in 2017, there has been a boom in dispensaries in Las Vegas. The state has issued over 300 dispensary licenses, with over 25 located within just two miles of The Strip.

With the legalization of recreational marijuana and the rise in cannabis tourism, Las Vegas has emerged as one of the best places to open a cannabis dispensary. Even the restrictions on public consumption cannot dampen the excitement, especially with cannabis lounges debuting in 2019, offering new opportunities for entrepreneurs. Additionally, events like MJBizCon provide valuable networking for aspiring business owners. By leveraging tourism and the vibrant industry, they can create unique experiences and target niche markets effectively.

Here’s an overview of how to open a dispensary in the Silver State:

• Follow a Regulated Framework: Nevada’s carefully regulated system covers both medical and recreational cannabis, overseen by the Nevada Department of Taxation.
• Secure a Marijuana Establishment License: Apply for this essential license, meeting all state regulatory requirements.
• Navigate Local Zoning Restrictions: Ensure your chosen location complies with local zoning laws for cannabis businesses.
• Comply with Operational Requirements: Adhere to Las Vegas’s specific rules for dispensary operations to ensure legal and seamless business setup.
  

5. Phoenix, Arizona

Phoenix is an excellent location for opening a dispensary. It was one of the fastest states to transition from medical to recreational marijuana use. After voters approved Proposition 207 in November 2020, recreational sales began in January 2021, marking a swift implementation period.

Swift legalization created a lot of new opportunities in the market, especially with the support for the cannabis market in Phoenix. Various cannabis-related events, such as the Errl Cup, celebrate the best local cannabis products and cultivators.

Lately, Phoenix has also witnessed a rise in cannabis tourism, with visitors flocking to experience the city’s vibrant cannabis culture. From visiting top dispensaries to staying in cannabis-friendly accommodations, Phoenix has become a go-to destination for enthusiasts. As the industry becomes more widely accepted, experts anticipate a continued upward trend in cannabis consumption.

The Arizona Department of Health Services oversees regulations for medical and recreational cannabis in Arizona. Entrepreneurs opening a dispensary in Phoenix must obtain a cannabis business license, comply with state and local regulations, and meet city-specific zoning and operational requirements. It is also advisable to obtain cannabis insurance specific to Arizona.

Check out our article on how to open a dispensary in Arizona to learn more.

6. Portland, Maine 

Maine voters legalized recreational cannabis back in 2016, but retail sales didn’t begin until 2020. While Maine’s population is low, the state sees large numbers of tourists every year, with Portland alone welcoming over 3 million visitors annually. Annual events like the Maine Cannabis Fair help create a strong culture around the plant. 

Not every municipality has opted in for recreational cannabis sales (Bar Harbor has opted multiple times not to allow retail sales of recreational cannabis), but every county allows for medical marijuana sales. Even so, the state brought in over $240 million from cannabis sales in 2024, highlighting the appetite for recreational cannabis. 

To open a dispensary in Portland, Maine, applicants must apply for a license with the Maine Office of Cannabis Policy with an existing business entity. An existing business plan is an important piece of any application, and applicants must have a location secured to be approved for a license. You’ll also need to:

• Secure funding
• Ensure state and local regulatory compliance, including strict security measures
• Obtain Maine-specific cannabis insurance

7. Anchorage, Alaska 

The farthest-flung state of the union is often forgotten about when it comes to cannabis, but weed has been recreationally legal in Alaska since 2014, before California. 

While Alaska has a small permanent population, the state welcomes over 3 million visitors annually, almost triple the number of residents. These visitors add $3.9 billion to Alaska’s economy in direct spending – and some of the money is on cannabis. Additionally, legal sales in Anchorage, Alaska, surpassed $108 million in 2024, showing the demand for cannabis even in smaller populations. 

The Alcohol & Marijuana Control Office, a subdivision of the State Department of Commerce, Community, and Economic Development,  runs the recreational cannabis program. Entrepreneurs seeking to open a dispensary in Anchorage must apply for and obtain a marijuana license, which must be renewed annually, secure funding, complete a background check, comply with local and state regulations, and pass a demonstration of compliance. It’s also recommended to have Alaska-specific cannabis insurance for your dispensary. 

8. Chicago, Illinois

Chicago is home to some of the cannabis industry’s largest and most successful companies, with a diverse range of cannabis businesses. However, it lags behind other metro areas in the sheer number of establishments, creating an opening for new entrepreneurs to establish a strong presence and meet growing demand.

Illinois has a regulatory framework for both medical and recreational cannabis, managed by the Illinois Department of Financial & Professional Regulation. Those interested in opening a dispensary must:

• Obtain a license
• Follow state regulations
• Comply with Chicago’s specific zoning and operational requirements.
  

However, there are arguments that Missouri may offer a more favorable environment than Illinois for opening a dispensary. Sales taxes and other factors play a role in consumer decisions and market stability. For a deeper comparison, check out our guide on Missouri vs. Illinois: Making Sense of Cannabis Industry Competition to determine which state best aligns with your business goals.

9. Albuquerque, New Mexico

Albuquerque offers an attractive opportunity for opening a dispensary following New Mexico’s legalization of recreational cannabis on March 31, 2021. The market saw rapid growth, with adult-use cannabis sales reaching $300 million in the first year alone. In the same year, the state also issued approximately 2,000 cannabis business licenses, which included 633 cannabis retailers, 507 manufacturers, 415 micro-producers, and 351 producers.

Additionally, Albuquerque hosts various cannabis events and expos, such as CannaCon Albuquerque. These gatherings bring together industry professionals, advocates, and consumers to explore the latest innovations in cultivation, business strategies, and legal insights within the cannabis industry.

The New Mexico Regulation and Licensing Department oversees cannabis regulations in the state. To open a dispensary in Albuquerque, entrepreneurs must complete several essential steps:

• Obtain a License: Apply for a Cannabis Retail License with the state and meet all licensing requirements.
• Secure Zoning Approval: Ensure your chosen location complies with Albuquerque’s zoning regulations for cannabis businesses.
• Implement Security Measures: Install state-mandated security systems to protect the facility and products.
• Prepare Financials: Show proof of financial stability to cover start-up and operational costs.
• Ensure Compliance: Adhere to state and city regulations, including operational, reporting, and employee training standards.
  

For a detailed guide on launching a dispensary, check out our article How to Open a Dispensary in New Mexico.

The market potential in Albuquerque is promising despite the increased competition within the adult-use market. The state’s licensing structure is friendly, and there is still untapped potential for cannabis business entrepreneurs.

10. Honorable Mention: Boulder, Colorado 

Since 2012, the recreational cannabis program has been overseen by the Marijuana Enforcement Division of the state Department of Revenue. Boulder is an outdoorsy suburb of Denver best known for its incredible hikes and exceptional craft cannabis. The steady stream of transplants from across the country and annual tourism swells bring in a constant influx of new people looking for quality cannabis products. Colorado is also host to number of cannabis consumer events, including Ganja Yoga Retreats.  

To open a dispensary here, you must: 

• Obtain a dispensary license (available only to Colorado residents who pass a background check) 
• Create a business plan, secure funding, and find a retail location 
• Comply with Boulder’s specific zoning and operational regulations, as well as state requirements 
• Secure Colorado-specific cannabis insurance. 

The Colorado market is one of the most established in the nation, and competition is fierce here, so this market is not for the faint of heart, which is why this city gets an honorable mention on our list. But for those visionary entrepreneurs who understand what it takes to grow true craft cannabis, the sky is the limit.

There is no “perfect” state to open a cannabis dispensary, as market conditions and regulations are constantly changing. This list highlights states and cities with stable frameworks and promising long-term potential. 

When selecting a location, it’s essential to weigh all key factors—including legal environment, ease of market entry, tax climate, and growth opportunities—each of which plays a significant role in your dispensary’s success. By carefully assessing these elements, you can make a more informed choice for your cannabis business.

AlphaRoot: Tailored Insurance Solutions for Cannabis Entrepreneurs

No matter where you decide to open your dispensary, specialized business insurance is crucial to protect your investment. AlphaRoot offers tailored insurance services for cannabis businesses across the United States, ensuring your venture has the coverage it needs to thrive. We serve dispensaries in all states including Washington, California, Rhode Island, Nevada, Illinois, Arizona, and New Mexico, providing reliable support in each unique regulatory landscape.Protecting your cannabis company can seem confusing; however, we’re a full-service insurance brokerage working with carriers worldwide to offer you the best coverage possible. We’re here to help! Please reach out to us today by email [email protected] or calling 646-854-1093 for a customized letter or learning more about your cannabis insurance options.